2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W722107
    Timonacic-d4 3066050-54-9 98%
    Timonacic-d4 (1,3-Thiazolidine-4-carboxylic acid-d4) is deuterium labeled Timonacic. Timonacic (1,3-Thiazolidine-4-carboxylic acid) is a thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects, and it can be used to study acute illnesses and liver diseases, by inducing reversal, it is also used in research on certain cancer cases.
    Timonacic-d4
  • HY-W724743
    Losartan azide 727718-93-6 98%
    Losartan azide is a click chemistry reagent containing an azide group and is a synthetic intermediate for the preparation of angiotensin AT1R-targeted renal PET imaging probe [18 F]fluoropyridine-losartan.
    Losartan azide
  • HY-W728761
    Voxelotor-d7 98%
    Voxelotor-d7 is the deuterium labeled Voxelotor (HY-18681). Voxelotor is a potent inhibitor of haemoglobin S (HbS) polymerization.
    Voxelotor-d7
  • HY-W738639
    18-Hydroxy-11-deoxy corticosterone 379-68-0 98%
    18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields.
    18-Hydroxy-11-deoxy corticosterone
  • HY-W740088
    Adrenochrome monoguanylhydrazone methanesulfonate 4009-68-1 98%
    Adrenochrome monoguanylhydrazone methanesulfonate (S-Adchnone) is an adrenochrome derivative that has a protective effect against radiation-induced damage of hematopoietic organs.
    Adrenochrome monoguanylhydrazone methanesulfonate
  • HY-W741706
    Butopamine hydrochloride 74432-68-1 98%
    Butopamine hydrochloride is an orally active inotropic compound. Butopamine hydrochloride increases heart rate more than Dobutamine (HY-15746A).
    Butopamine hydrochloride
  • HY-W741999
    Metaproterenol-d7-1 hemisulfate 98%
    Metaproterenol-d7-1 (hemisulfate) is deuterium labeled Metaproterenol (hemisulfate). Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity.
    Metaproterenol-d7-1 hemisulfate
  • HY-W744225
    Tyramine-d4 hydrochloride 1188266-06-9 98%
    Tyramine-d4 hydrochloride is the deuterium labeled Tyramine hydrochloride (HY-W016823). Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods.
    Tyramine-d4 hydrochloride
  • HY-W746625
    all-cis-4,7,10,13,16-Docosapentaenoic acid methyl ester 31930-67-3 98%
    all-cis-4,7,10,13,16-Docosapentaenoic acid methyl ester (all-cis-4,7,10,13,16-DPA methyl ester) is the methyl ester derivative of all-cis-4,7,10,13,16-Docosapentaenoic acid, that can be used as a nutritional supplement to increase all-cis-4,7,10,13,16-Docosapentaenoic acid intake. all-cis-4,7,10,13,16-Docosapentaenoic acid is a long-chain polyunsaturated fatty acid, that plays a role in cardiovascular health, neuroprotection, and inflammation regulation.
    all-cis-4,7,10,13,16-Docosapentaenoic acid methyl ester
  • HY-W747703
    Hippuric acid-13C6 1163160-18-6 98%
    Hippuric acid-13C6 (Benzoylglycine-13C6) is 13C labeled Hippuric acid. Hippuric Acid is an orally active metabolite. Hippuric Acid can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Hippuric Acid decreases NRF2, MMP9 and leads to ROS accumulation. Hippuric Acid activates TGFβ/SMAD signaling. Hippuric Acid improves hyperuricemia and colitis. Hippuric Acid can also be used in cardiovascular disease research. .
    Hippuric acid-13C6
  • HY-W747992
    Indicaxanthin 2181-75-1 98%
    Indicaxanthin is a natural water-soluble betalain, presenting a yellow-orange color. Indicaxanthin possesses free radical scavenging ability and can inhibit lipid peroxidation, reducing the formation of malondialdehyde (MDA). Indicaxanthin can be used in the research of cardiovascular diseases and diabetes.
    Indicaxanthin
  • HY-W749323
    21-Hydroxyeplerenone 334678-67-0 98%
    21-Hydroxyeplerenone is a major metabolite of the mineralocorticoid receptor antagonist Eplerenone (HY-B0251). 21-Hydroxyeplerenone is formed from eplerenone by the cytochrome P450 (CYP) isoform CYP3A4.
    21-Hydroxyeplerenone
  • HY-W751400
    Solasodine hydrochloride 6106-33-8 98%
    Solasodine (Purapuridine) hydrochloride is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine hydrochloride induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine hydrochloride has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities.
    Solasodine hydrochloride
  • HY-W752055
    (Rac)-Nebivolol-d4 hydrochloride 2701283-32-9 98%
    (Rac)-Nebivolol-d4 hydrochloride is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1-adrenergic receptor with an IC50 of 0.8 nM.
    (Rac)-Nebivolol-d4 hydrochloride
  • HY-W755295
    Mabuterol hydrochloride 54240-36-7 98%
    Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB.
    Mabuterol hydrochloride
  • HY-W759845
    Aficamten-d3 98%
    Aficamten-d3 (CK-274-d3) is deuterium labeled Aficamten. Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM).
    Aficamten-d3
  • HY-W778391
    Bisphenol A-13C2 263261-64-9 98%
    Bisphenol A-13C2 is 13C labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders.
    Bisphenol A-13C2
  • HY-W778574
    BAPTA tetracesium 480436-84-8 98%
    BAPTA tetracesium is a selective and cell-impermeant chelator for calcium. BAPTA tetracesium has high selectivity against magnesium and calcium. BAPTA tetracesium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
    BAPTA tetracesium
  • HY-W782096
    Salvianolic acid H 444179-57-1 98%
    Salvianolic acid H is a potent acetylcholinesterase (AChE) inhibitor.
    Salvianolic acid H
  • HY-W783623
    1,3-Didocosahexaenoyl glycerol 140670-42-4 98%
    1,3-Didocosahexaenoyl glycerol (DG(22:6/0:0/22:6); 1,3-Didocosahexaenoin) is an ω-3 polyunsaturated fatty acid, which exhibits cardioprotective effects in rat myocardial ischemia/reperfusion (I/R) injury model through conjugation with Poly-l-glutamic acid (PGA).
    1,3-Didocosahexaenoyl glycerol
Cat. No. Product Name / Synonyms Application Reactivity